Nicotine slows brain aging by reduction of appetite

Nicotine has long been reported as an agent that could delay the onset of Alzheimer’s memory loss or even reduce symptoms of the disease.  [British Journal Addiction 1991; Psychopharmacology 1983]

The most recently published science says blockage of the nicotine receptors on brain cells could also protect against the onset of Alzheimer’s disease by virtue of its ability to reduce appetite. [Good Therapy Sept 6, 2016]  This study is very pertinent to the development of treatments for Alzheimer’s disease since midlife obesity decreases blood flow to the brain which researchers believe can lead to Alzheimer’s disease memory loss. [Current Alzheimer’s Research 2014]

While it is widely known that calorie restricted diets control body weight and may protect against mental decline with advancing age. [Current Pharmaceutical Design 2011]  The use of an appetite suppressant like nicotine would be a novel approach to delay Alzheimer’s disease.

While the reverse-nicotine story is just now reaching the news media, the original study cited as the origin of the news report was published in 2015. [Journal of Toxicology Nov 2015]

While smokers do receive some nicotine as they smoke, cigarette smoking impairs blood circulation to the brain by its ability to inhibit a blood vessel-dilating agent nitric oxide.  [Journal Pharmacological Science Aug 2016]

High levels of homocysteine, an undesirable blood protein, also impairs blood flow to the brain.  [Pflugers Archives Sept 2016] B vitamins reduce homocysteine levels.

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