Nicotinamide adenine dinucleotide (NAD) is found in all living cells. NAD carries electrons and NADH is the form of NAD that can donate electrons and quell free radicals but also to create cell energy in the form of adenotriphosphate (ATP). Readers can view a simple video to explain NAD. [How NAD Works]
Niacin in food and supplements and niacinamide provided in multivitamins along with other niacin-like precursors of NAD such as nicotinamide riboside and nicotinamide mononucleotide promote the production of NAD itself. The provision of nicotinamide mononucleotide to young mice mitigates a decline in cellular energy, age-related weight gain, results in greater physical activity, improved insulin sensitivity and allays visual deterioration. The provision of NAD intermediates is considered an effective anti-aging intervention. [Cell Metabolism Oct 2016] Since millions of adults acquire niacinamide from multivitamins it is unclear to this health investigator why all the designer forms of niacin need to be supplemented at considerable greater cost than niacinamide. Nonetheless, health seekers are sure to be bombarded by research studies in coming years that promote intermediate forms of niacin as anti-aging pills. [Science Daily Oct 27 2016] The red wine molecule resveratrol also directly stimulates NADH that stimulates the Sirtuin3 gene to produce more energy (ATP) in the cell energy compartments (mitochondria). [Journal Biological Chemistry Dec 20, 2013] NAD agents join the anti-diabetic drug metformin and the mTOR inhibitor Rapamycin as anti-aging drugs.