Magnesium makes good companion with calorie-restricted longevity diets

Magnesium, acting alone or in response to calorie restricted diets, combats destabilization of lifespan-shortening RNA-DNA hybrids in the human genome.  Calorie restriction can promote ribosomal DNA stability by abolishing deleterious accumulations of nucleic acid structures called R-loops.  The aberrant accumulation compromises genome stability in different organisms including humans.  Magnesium as a biochemical signal of beneficial calorie restriction, establish magnesium as an R-loop suppressing biological metal, and indicate that magnesium supplementation should be considered in longevity regimens. [Nucleic Acids Research Aug 29, 2016]

Leave a Reply

Your email address will not be published. Required fields are marked *