Laboratory mice fed a high-fat, high-sugar or a high-protein diet of equal caloric value compared

As anticipated, laboratory mice given a high sugar or high-fat diet gained more weight than animals fed a high-protein diet.  The diets of all three groups were equal in calories.  It is the composition of food, not the caloric intake, that governs weight gain and development of fatty liver.  The adverse effects of the high-fat and high-sugar diets were associated with changes in gut bacteria.  [World Journal Gastroenterology Aug 28, 2016] However, be aware that an iron-rich source of protein like red meat is also a risk factor for fatty liver disease. [Journal Human Nutrition Dietetics Aug 2015]

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