Yes, iron deficiency is associated with restless leg syndrome

You lay on your bed to go to sleep and find your legs begin uncontrollably kicking.  Called restless leg syndrome, doctors appear to be in the dark over what causes this problem.

As circulation slows, less oxygen is delivered to muscles in the legs and they contract when deprived of oxygen.  Anemic individuals by definition would and do experience restless leg syndrome.  So do pregnant women who may have low hemoglobin levels and are in need of supplemental iron to make more red blood cells.  Increased iron intake resolves restless leg syndrome in pregnancy while magnesium intake exacerbates the problem. [Journal Maternal Fetal Neonatal Medicine March 2016]

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