In 1950 persons over age 80 numbered less than 14 million. By the year 2050 it is projected there will be almost 379 million over-age 80 adults in the world, with 20% of them having some level of mental decline (dementia). [World Population Ageing] Researchers say “new pharmacological alternatives” are needed to slow the rate of mental decline in the aged and simultaneously reduce health care costs. [Perspective 2016]
A major problem is the loss of connectivity between brain cells (neurons) with advancing age.The red wine molecule resveratrol (rez-vair-uh-trol) is proposed as an agent that will delay aging, particularly in the brain, and improve memory. The dramatic effect of resveratrol in maintaining connectivity in the brain is seen in the following graphic.